RAF Typhoon jets have operated alongside French aircraft in a combined operation targeting an underground arms cache in Syrian territory operated by the IS group, according to the British defence ministry.
The site, located using reconnaissance, was believed to be storing arms and explosives, the statement said, and was situated in mountains just north of the historic site of Palmyra in the heart of Syria.
"Our aircraft utilized Paveway IV guided bombs to hit a several entry passages providing entry to the depot... preliminary assessments indicate the objective was successfully hit," the ministry announced.
There was no sign of any harm to civilians in the attack conducted Saturday night and every plane involved made a safe return, the defence officials confirmed.
The British jets were backed up by a Voyager refuelling tanker.
The Islamic State group - alternatively referred to as ISIS - established militant control over parts of Syria and Iraq before its territorial defeat in 2019.
"This action shows British leadership, and resolve to work closely with allied nations, to stamp out any re-emergence of IS and their harmful and extremist ideologies in the region," the British Defence Secretary the Defence Secretary stated.
UK warplanes have carried out patrols over Syrian airspace to "deter any attempted comeback" of the group subsequent to its routing at the Baghuz confrontation in 2019, the MoD reported.
"I want to thank the personnel of the UK armed forces involved in this mission for their skill and their valour," Healey added. "They were among a great many British personnel deployed over the holidays. This mission, to take out dangerous terrorists who endanger our way of life, demonstrates how our armed forces are always on standby, all year round, protecting the UK within its borders and strong abroad."
In December, the US military executed what it described as a "major assault" against Daesh sites in the country, after an ambush resulted in the deaths of two US troops and a civilian interpreter in the Palmyra area.
The UN says Daesh still has between 5,000 and 7,000 militants in Iraq and Syria.